Stomatologist № 3 (34) – 2019, pp. 46-50                                                                                                                               SCIENTIFIC PUBLICATION


Diagnostic significance of the elastasic activity of the serum of the blood and the oral liquid of patients with inflammatory processes of the maxillofacial region and neck


A.A. Kabanova

MD, PhD, Associate professor, Vitebsk State Medical University, Vitebsk, Belarus

https://doi.org/10.32993/stomatologist.2019.3(34).3

ABSTRACT
The aim of the study is to determine the diagnostic significance of the elastase activity of blood serum and oral fluid of patients with inflammatory processes in the maxillofacial region of various severity.
Objects and methods. A survey of 198 patients with infectious and inflammatory processes of the maxillofacial area. The reference group consisted of 50 healthy individuals. Determination of the activity of elastase in the blood and oral fluid was performed according to a modified method proposed by Kyung-Hwan and Kim Hyun.
Results and discussion. Inflammatory diseases of the maxillofacial area and neck of odontogenic etiology are accompanied by an increase in the RJ elastase activity in patients of all subgroups with different prevalence of the process, whereas serum elastase activity is increased only in patients with acute odontogenic osteomyelitis complicated by phlegmons of more than two spaces (subgroup 3) and 4). The elastase activity of oral fluid by the time of completion of inpatient treatment does not differ from the indicators of the reference group, with the exception of patients with phlegmons of the mouth floor, the studied indicator remains elevated for a longer period, and at the end of treatment reaches a significantly lower level than healthy individuals (p <0,05), which may be due to the depletion of elastase secreted by neutrophils against the background of its long-lasting active production in severe inflammatory processes. This, in turn, may indicate a decrease in the patient’s protective mechanisms during clinical recovery and a high degree of risk of developing another pathology.
Conclusion. The results indicate a high diagnostic and prognostic significance of determining the elastase activity of blood serum and oral fluid in the development of infectious and inflammatory diseases of the maxillofacial area and neck.

Keywords: infectious and inflammatory diseases, maxillofacial region, elastase activity

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Correspondence to: Е-mail: arinakabanova@mail.ru