Dentist № 4 (39) – 2020, pp. 54-60                                                                                                   SCIENTIFIC PUBLICATION

Fundamentals of mucology: oral mucositis

M.I. Degtyarevaa, L.A. Kazekob

aBelarusian State Medical University, Minsk, Belarus
bMD, PhD, Associate Professor, Belarusian State Medical University, Minsk, Belarus

https://doi.org/10.32993/dentist.2020.4(39).3

ABSTRACT
Oral mucositis is one of the most common complications observed in radiation and/or chemotherapy for cancer. The appearance of oral mucositis is caused by damage to cells and tissues by radiation exposure or the action of high doses of cytostatic drugs, which is accompanied by pain in the oral cavity, a violation of taste, the appearance of ulcers and erosions on the mucous membrane.
The aim of the study is to determine the significance of the experiment in order to study methods of prevention and treatment of oral mucositis.
Objects and methods. A retrospective analysis of scientific research, including the development of an experimental model of oral mucositis on PubMed, SemanticScholar and Scopus databases.
Results and discussion. Today, methods of prevention and treatment of oral mucositis are not standardized and none of the existing methods is not recognized as sufficiently effective.
Conclusion. Treatment and prevention of oral mucositis require careful further study in order to improve existing methods and develop new ones. The significance of the experiment in the conditions of scientific research is reflected; the existing experimental models of oral mucositis, which can be used for its further study, are presented and described.

Keywords: oral mucositis, radiotherapy, chemotherapy, experiment

References 

  1. Islamov R.A. Metodologiya eksperimenta s ispol’zovaniem laboratornykh zhivotnykh [Methodology of the experiment using laboratory animals]. Vestnik KazNMU – Bulletin Of KazSMU. 2016, no. 1, pp. 489–492.
  2. Ishberdina T.S., Suleymanova G.F. Laboratornye zhivotnye, ispol’zuemye dlya issledovaniy. Materialy VII Mezhdunarodnoy studencheskoy nauchnoy konferentsii «Studencheskiy nauchnyy forum» [Laboratory animals used for research. Materials of the VII international student scientific conference «Student scientific forum»]. Elektronnyy sbornik. – Electronic collection. Available at: https://scienceforum.ru/2015/article/2015012125
  3. Leont’eva I.V. Morfofunktsional’naya kharakteristika slizistoy obolochki polosti rta pri vvedenii tsitostatikov. Avtoref: Diss. kand. med. nauk [Morphofunctional characteristics of the oral mucosa during administration of cytostatics. Abstract: Diss. Medical candidate. sciences]. Sankt-Peterburg, 2011. 19 p.
  4. Lukashov R. Organizatsionnye momenty ispol’zovaniya laboratornykh zhivotnykh v eksperimental’noy meditsine [Organizational aspects of using laboratory animals in experimental medicine]. Elektronnyy resurs. – Electronic resource. Available at: http://vnauke.by/news/Organizacionnye-momentyispolzovaniya-laboratornyx-zhivotnyx-v-eksperimentalnoj-medicine
  5. Mironov A.N., Bunyatyan N.D., Vasil’eva A.N. Rukovodstvo po provedeniyu doklinicheskikh issledovaniy lekarstvennykh sredstv. Ch. 1. [Guidelines for conducting preclinical drug research. Part 1]. M.: Grif i K, 2013. 944 p.
  6. Mironov A.N., Bunyatyan N.D., Vasil’eva A.N. Rukovodstvo po provedeniyu doklinicheskikh issledovaniy lekarstvennykh sredstv. Ch. 2. [Guidelines for conducting preclinical drug research. Part 2]. M.: Grif i K, 2013. 536 p.
  7. Zhermen E.R., Dario A.K. Primenenie melatonina dlya lecheniya i/ili predotvrashcheniya mukozita [Use of melatonin for the treatment and/or prevention of mucositis]. Patent №217.015.7A92, Universidad De Granada.
  8. Chadaev V.E. Model’nye ob”ekty v meditsine i veterinarii [Model objects in medicine and veterinary medicine]. Vestnik problem biologii i meditsiny. Poltava. – Bulletin of problems of biology and medicine. Poltava. 2012, no. 2 (95), pp. 140–145.
  9. Yartseva A.A. Patofiziologicheskie osnovy primeneniya disul’fidov glutationa v kachestve sredstv profilaktiki i lecheniya khimioluchevykh oral’nykh mukozitov u bol’nykh rakom orofaringeal’noy oblasti. Avtoref: Diss. dokt. med. nauk [Pathophysiological basis for the use of glutathione disulfides as a means of prevention and treatment of chemoradial oral mucositis in patients with oropharyngeal cancer. Abstract: Diss. doct. medical. sciences]. Sankt-Peterburg, 2015. 40 p.
  10. Alkesh P., Rajesh S., Chandrashekhar V.M. [et al.] A rat model against chemotherapy plus radiation-induced oral mucositis. Saudi pharmaceutical journal, 2013, vol. 21, no. 4, pp. 399–403.
  11. Alvarino-Martin C., Sarrion-Perez M.G. Prevention and treatment of oral mucositis in patients receiving chemotherapy. Journal of clinical and experimental dentistry, 2014, vol. 6, no. 1, pp. 74–80.
  12. Barbosa M.M., Araujo A.A. Telmisartan modulates the oral mucositis induced by 5-fluorouracil in hamsters. Front Physiol, 2018, vol. 9, pp. 1–12.
  13. Chaveli-Lopez B., Bagan-Sebastian J.V. Treatment of oral mucositis due to chemotherapy. Journal of clinical and experimental dentistry, 2016, vol. 8, no. 2, pp. 1–9.
  14. Georgiou M., Patapatiou G., Domoxoudis S. Oral Mucositis: understanding the pathology and management. Hippokratia, 2012, vol. 6, no. 3, pp. 215–216.
  15. Kumar S. Pain management – current issues and opinion. InTech: Gabor Racz, 2012. 554 p.
  16. Miyamoto C.T. Reducing the incidence and severity of oral mucositis – Can it be done? US Oncological Disease, 2007, vol. 1, no. 2, pp. 18–21.
  17. Sonis S.T., Elting L.S., Keefe D. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology and consequences for patients. Cancer, 2004, vol. 100, pp. 1995–2025.

Correspondence to:  Е-mail: dr.mdegtyareva@yandex.by