Dentist № 1 (48) – 2023, pp. 60-66                                                                                                             SCIENTIFIC PUBLICATION

The use of domestic herbal medicinal product “Macleay’s Leaves” in patients with chronic generalized periodontitis

Yu.L. Denisovaa, K.Y. Egorovab

aMD, PhD, DMSci, Professor, Belarusian State Medical University, Minsk, Belarus
b Belarusian State Medical University, Minsk, Belarus

https://doi.org/10.32993/dentist.2023.1(48).10

ABSTRACT
Due to the widespread and long antimicrobial drug’s use in periodontology, in particular antiseptics, the problem of the periopathogenic microorganism’s resistance development to this drug’s group is now increasingly emerging. Consequently, the issue of developing and introducing new alternative antimicrobial herbal agents into clinical practice is being updated.
The aim of the study. To evaluate the Macleay’s leaves use effectiveness in treatment of patients with chronic generalized periodontitis.
Objects and methods. The study was conducted on the basis of Department of Periodontology of BSMU. It was attended by 30 patients of practically healthy both sexy patients aged 45-60 years with a diagnosis of chronic generalized periodontitis of moderate severity. The patients were divided into 2 groups (A and B) of 15 patients each. Patients of both groups were motivated by risk factors of major dental diseases, professional oral hygiene with mandatory root planning procedure. Then, for 7 days, patients of group B were instilled daily with periodontal pockets with a decoction of Macleay’s leaves. Comparative analysis of both group’s patients was carried out on the 1 th day, the 7th day of the study, after 1 and 2 weeks, after 1 and 3 months of the study and was based on n the data of indicators of objective studies of the periodontal tissues state.
Results and discussion. According to the results of this study, the herbal drug “Macleay’s leaves” has shown it’s high efficiency and can be used in the drug therapy of chronic generalized periodontitis.
Conclusion. A decoction of the drug “Macleay’s leaves” in patients with chronic generalized periodontitis has an antimicrobial effect, which is expressed in a decrease in the concentration of periodontopathogenic microorganisms, which helps to reduce the intensity of the inflammatory process of periodontal tissues, reduce the index OHI-S, GI, PMA, PI.

Keywords: Leaves Macleay, drug, antimicrobial, periodontology

References 

  1. Abizov E.A., Tolkachev O.N. Sangviritrin [Sangviritrin]. Medicinskaja pomoshh’. – Medical assistance. 2003, no. 4, pp. 41–45.
  2. Adgina V.V. Izuchenie antimikrobnyh svojstv sangviritrina i vhodjashhih v nego komponentov [Study of the antimicrobial properties of sanguirythrin and its constituent components]. K.: Naukova dumka, 1988. 78 p.
  3. Bortnikova L.V., Krepkova L.V., Shkarenkov A.A Sravnitel’noe toksikologicheskoe izuchenie lekarstvennyh form sangviritrina, rekomendovannyh v pediatrii [Demonstrative-toxicological support of dosage forms of sanguiritrin recommended in pediatrics]. Chelovek i lekarstvo: tez. dokl. Ros. nac. kongr. – Man and medicine: abstract. report Ros. nat. congr. M., 2004. 549 p.
  4. Vichkanova S.A., Krutikova N.M. Klinicheskoe primenenie sangviritrina pri disbakterioze [Clinical picture of sanguine ritrinova infection in dysbacteriosis]. Poliklinika. – Polyclinic. 2012, no. 2, pp. 93–96.
  5. Dedova L.N., Kandrukevich O.V. Periodontologija: lekarstvennaja terapija v koncepcii biologicheskoj sistemy periodonta [Periodontology: drug therapy in the concept of periodontal biological system]. Stomatolog. Minsk. – Dentist. Minsk. 2018, no. 4, pp. 101–107.
  6. Dedova L.N., Denisova Ju.L., Solomevich A.S. Podderzhivajushhaja terapija boleznej periodontal [Maintenance therapy of periodontal diseases]. Stomatolog. Minsk. – Dentist. Minsk. 2015, no. 4 (19), pp. 79–85.
  7. Dedova L.N., Denisova Ju.L., Kandrukevich O.V., Solomevich A.S., Rosenik N.I. Rasprostranjonnost’ boleznej periodonta, kariesa kornja zuba, chuvstvitel’nosti dentina i zubocheljustnyh deformacij v Respublike Belarus’ po rezul’tatam obsledovanija naselenija v vozrastnyh gruppah 35-44, 45-54 i 55-64 goda [The prevalence of periodontal diseases, tooth root caries, dentin sensitivity and dentoalveolar deformities in the Republic of Belarus according to the results of a survey of the population in the age groups of 35-44, 45-54 and 55-64 years]. Stomatolog. Minsk. – Dentist. Minsk. 2016, no. 1 (20), pp. 9–15.
  8. Denisova Ju.L., Dedova L.N. Sostojanie al’veoljarnoj kostnoj tkani pacientov s hronicheskim generalizovannym periodontitom (parodontitom) v sochetanii s zubocheljustnymi deformacijami [The state of alveolar bone tissue in patients with chronic generalized periodontitis (periodontitis) in combination with dentoalveolar deformities]. Parodontologija – Periodontology. 2012, vol. 17, no. 2 (63), pp. 41–44.
  9. Kolchanova N.Je. Rol’ mikroflory i ejo sposobnost’ formirovat’ biopljonku v patogeneze hronicheskogo periodontita [The role of microflora and its ability to form a biofilm in the pathogenesis of chronic periodontitis]. Vestnik VGMU. – Bulletin of the VSMU. 2017, vol. 16, no. 5, pp. 127–135.
  10. Bortnikova V.V., Shkarenkov A.A., Kuznecov Ju.B. Immunostimulirujushhij jeffekt antimikrobnogo fitopreparata sangviritrin [Immunostimulatory effect of the antimicrobial phytopreparation sangviritrin]. Chelovek i lekarstvo: tez. dokl. Ros. nac. kongr. – Man and medicine: abstract. report Ros. nat. congr. M., 2004. 580 p.
  11. Rubnikovich S.P., Denisova Ju.L., Andreeva V.A., Panasenkova G.Ju., Homich I.S. Klinicheskaja ocenka jeffektivnosti primenenija mezenhimal’nyh stvolovyh kletok v lechenii recessii desny v jeksperimente [Clinical evaluation of the effectiveness of the use of mesenchymal stem cells in the treatment of gingival recession in the experiment]. Stomatolog. Minsk. – Dentist. Minsk. 2018, no. 2 (29), pp. 36–44.
  12. Sachek M.G., Kosinec A.N., Adamenko G.P. Immunologicheskie aspekty hirurgicheskoj infekcii [Immunological aspects of surgical infection]. Vitebsk, 1994. 138 p.
  13. Frolova A.V., Poisk lekarstvennyh rastenij dlja lechenija pacientov s hirurgicheskoj infekciej. Maklejja [Search for medicinal plants for the treatment of patients with surgical infection. MacLeay]. Vestnik farmacii. – Bulletin of Pharmacy. 2005, no. 4 (30), pp. 79–86.
  14. Fangying L., Xueduan L., Huang H., Fu S. The Macleaya cordata Symbiont: Revealing the Effects of Plant Niches and Alkaloids on the Bacterial Community. Front Microbiol., 2021, pp. 3–13.
  15. Jalali F., Ellett F., Balani P., Duncan M.J., Dewhirst F.E., Borisy G.G., Irimia D. No man’s land: Species-specific formation of exclusion zones bordering Actinomyces graevenitzii microcolonies in nanoliter cultures. Microbiology Open., 2021, pp. 3–13.

Correspondence to:  Е-mail: denisova_yul@mail.ru