Stomatologist №4 (31) – 2018, pp. 34-38                                                                                                                                  Scientific publication

Effect of the beta-lactamase activity level in the oral fluid on the efficacy of the antibiotic therapy

I.V. Zhil’cova, V.M. Semenova, T.A. Torosjanb, N.A. Movsesjanc

aMD, PhD, DMSci, Professor, Vitebsk State Medical University, Vitebsk, Belarus
bMD, PhD, Associate Professor, Vitebsk State Medical University, Vitebsk, Belarus
cVitebsk State Medical University, Vitebsk, Belarus

https://doi.org/10.32993/stomatologist.2018.4(31).6

ABSTRACT
The resistance of oral microorganisms to beta-lactam antibiotics is of great clinical importance. It is assumed that this resistance is primarily mediated by bacterial beta-lactamases.
The aim of the study is to evaluate the effect of the beta-lactamase activity level in the oral fluid on the efficacy of antibiotic therapy.
Objects and methods. The clinical study had a cross-sectional design that was linear and prospective. Two main groups (therapeutic and surgical) and the control one were studied. Results and discussion. The oral fluid of patients with therapeutic and surgical diseases in 97.4% of cases has beta-lactamase activity, the level of which varies widely from the minimum (fraction of a percent) to the maximum (94.3%).
Conclusion.. We formulated the clinical guidelines for optimizing the start of the empirical antibiotic therapy.

Keywords: infection, maxillofacial surgery, antibiotics

References

  1. Kabanova A.A. Pokazateli mikrotsirkulyatsii u patsientov s flegmonami chelyustno-litsevoy oblasti [The microcirculation parameters at the patient with phlegmons of the maxillofacial area]. Stomatolog. Minsk. – Stomatologist, Minsk. 2016, no. 1 (20), pp. 66-68.
  2. Kabanova A.A., Goncharova A.I., Kabanova S.A. BAPNA-amidaznaya i elastaznaya aktivnost rotovoy zhidkosti patsientov s gnoyno-vospalitelnyimi zabolevaniyami chelyustno-litsevoy oblasti [BAPNA-amidase and elastase activity of the oral fluid of patients with purulent-inflammatory diseases of the maxillofacial region]. Stomatolog. Minsk. – Stomatologist, Minsk. 2014, no. 2 (13), pp. 7-10.
  3. Miranovich S.I., Petrovskiy E.V. Bakteriologicheskaya harakteristika flegmon chelyustno-litsevoy oblasti [Bacteriological characteristics of maxillofacial phlegmon]. Stomatolog. Minsk. – Stomatologist, Minsk. 2013, no. 1 (8), pp. 69-72.
  4. Pohodenko-Chudakova I.O., Ignatovich A.P. Sravnitelnaya otsenka effektivnosti lekarstvennyih sredstv, ispolzuemyih dlya profilaktiki oslozhneniy pri ambulatornyih hirurgicheskih vmeshatelstvah v polosti rta [Comparative evaluation of the effectiveness of drugs used to prevent complications of outpatient surgical interventions in the oral cavity]. Stomatolog. Minsk. – Stomatologist, Minsk. 2012, no. 2 (5), pp. 43-46.
  5. Sidorenko S.V. Issledovanija rasprostranenija rezistentnosti k antibiotikam: prakticheskoe znachenie dlja mediciny [Studies on the spread of antibiotic resistance: practical for medicine] Infekcii i antimikrobnaja terapija. – Infections and antimicrobial therapy, 2002, vol. 4, no. 2, pp. 38-41.
  6. Strachunskij L.S., Belousov Ju.B. Prakticheskoe rukovodstvo po antiinfekcionnoj himioterapii [Practical Guide to Anti-infective Chemotherapy]. Moscow, 2002, pp. 32-39.
  7. Shargorodskij A. G. Vospalitel’nye zabolevanija cheljustno-licevoj oblasti i shei [Inflammatory diseases of the maxillofacial area and neck] Moskva: MedicinaPubl., 1993, 352 p.
  8. Elander R. Industrial production of beta-lactam antibiotics. Applied microbiology and biotechnology, 2003, vol. 61 (56), pp. 385-392.
  9. Elisabeth M., Clara D., Gary C. [et al.] Bacterial diversity in the oral cavity of ten healthy individuals. ISME J., 2010, vol. 4 (8), pp. 962-974.
  10. Giamarellou H., Antoniadou A. Epidemiology, diagnosis, and therapy of fungal infections in surgery. Infect. Control Hosp. Epidemiol., 1996, vol. 17, no. 8, pp. 558-564.
  11. Guobis Ž., Kareivienė V., Basevičienė N. [et al.] Microflora of the oral cavity in patients with xerostomia. Medicina (Kaunas), 2011, vol. 47 (12), pp. 646-651.
  12. Tets V.V., Tets G.V., Vikina D.S. [et al.] Unknown pathogens from the human oral microflora of interest for otorhinolaryngology. Vestn. Otorinolaringol., 2014, vol. 1, pp. 33-36.
  13. Elander R. Industrial production of beta-lactam antibiotics. Applied microbiology and biotechnology, 2003, vol. 61 (56), pp. 385–392.
  14. Elisabeth M., Clara D., Gary C. [et al.] Bacterial diversity in the oral cavity of ten healthy individuals. ISME J., 2010, vol. 4 (8), pp. 962–974.
  15. Giamarellou H., Antoniadou A. Epidemiology, diagnosis, and therapy of fungal infections in surgery. Infect. Control Hosp. Epidemiol., 1996, vol. 17, no. 8, pp. 558–564.
  16. Guobis Ž., Kareivienė V., Basevičienė N. [et al.] Microflora of the oral cavity in patients with xerostomia. Medicina (Kaunas), 2011, vol. 47 (12), pp. 646–651.
  17. Tets V.V., Tets G.V., Vikina D.S. [et al.] Unknown pathogens from the human oral microflora of interest for otorhinolaryngology. Vestn. Otorinolaringol., 2014, vol. 1, pp. 33–36.

Correspondence to: Е-mail: narine.movsesyan@list.ru