Dentist № 1 (48) – 2023, pp. 26-31                                                                                                             SCIENTIFIC PUBLICATION

Morphological study of bone tissue regeneration in laboratory animals during implantation of zirconium dioxide granules with bimodal pore distribution

A.G. Rogozhnikova, O.A. Shuliatnikovab, G.I. Rogozhnikovc, L.A. Chetvertnyha

aMD, PhD, Associate Professor, Perm State Medical University named by E.A. Vagner, Perm, Russia
bMD, PhD, DMSci, Associate Professor, Perm State Medical University named by E.A. Vagner, Perm, Russia
cMD, PhD, DMSci, Professor, Perm State Medical University named by E.A. Vagner, Perm, Russia

https://doi.org/10.32993/dentist.2023.1(48).4

ABSTRACT
The aim of the study was a morphological assessment of the regenerative abilities of the bone tissue of experimental animals (rabbits) during implantation of samples of cerium dioxide-stabilized zirconium dioxide ceramics in the form of granules with bimodal pore distribution
Objects and methods. For the experimental part of the work, a technology was developed for producing granules of modified zirconium dioxide with a size of 0,7-1,0 mm with a porosity of up to 80 %, with a bimodal distribution of micropores of 2,0-4,5 microns and nanopores of up to 10,0 nm. Fragments of the mandibular bone tissue of experimental animals from the implantation zone of modified zirconium dioxide granules served as objects for the morphological method of investigation.
Results and discussion. Results of the study showed that the high porosity of zirconium dioxide ceramic granules with a bimodal distribution of micro- and nanopores contributes to their denser contact with bone tissue structures. Zirconium dioxide granules are an inert material containing hydroxyappatite crystals and contribute to the effective process of reparative histogenesis of bone tissue and its vascularization, ensuring a tight connection without signs of development of pathological tissue changes in the area of the implanted ceramic material.
Conclusion. The use of zirconium dioxide granules in practical dentistry is promising to accelerate and improve the quality of bone regeneration during sinus lifting with the direct installation of a dental implant; to eliminate defects that are adjacent to the bone tissue implant by filling bone defects; to build up or reconstruct the bone tissue of the maxillofacial region to maintain a high degree of aesthetic result.

Keywords: dentistry, implantation, bone tissue, zirconium dioxide, granules, experiment

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