Dentist № 2 (61) – 2026, pp. 35-20                                                                                                                        REVIEWS, EDUCATIONAL ARTICLES

Evaluation of the effectiveness of hyaluronic acid application in plastic surgery of the soft tissues of the oral mucosa

M.S. Mutsyuka, A.A. Kabanovab

aVitebsk State Medical University, Vitebsk, Belarus
bMD, PhD, DMSci, associate professor, Vitebsk State Medical University, Vitebsk, Belarus

ABSTRACT
The aim of the study. A systematic review of current data on the applications of hyaluronic acid in plastic surgery of oral mucosal soft tissues.
Objects and methods. To systematize current data on the potential applications of hyaluronic acid in plastic surgery of oral mucosal soft tissues. An analysis of scientific publications from the Scopus, Web of Science, and PubMed databases for the period 2010–2025 was conducted. The reviewed articles focused on the use of hyaluronic acid in the surgical treatment of gingival recession and other soft tissue and bone defects of the oral cavity.
Results and discussion. Hyaluronic acid possesses unique physicochemical properties (hygroscopicity, viscoelasticity), promotes wound healing, and exhibits bacteriostatic and anti-inflammatory effects. Several clinical studies have shown that the use of hyaluronic acid in combination with a coronally advanced flap improves aesthetic outcomes and reduces postoperative discomfort. However, recent systematic reviews (Talebi Ardakani et al., 2025; Kalimeri et al., 2024) indicate heterogeneity in the evidence base. Hyaluronic acid demonstrates the greatest potential when combined with other biomaterials, as well as an alternative to enamel
matrix derivatives.
Conclusion.  Hyaluronic acid is a safe and promising agent in regenerative periodontal surgery. A key direction for future research is the standardization of application protocols, taking into account the initial tissue phenotype.

Keywords: hyaluronic acid, gingival recession, oral plastic surgery

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Correspondence to:  E-mail: mmcom1992@mail.ru