Dentist № 3 (54) – 2024, pp. 38-47                                                                                                                        SCIENTIFIC PUBLICATION

Morphological changes in periodontal tissues in laboratory animals with adjuvant-induced arthritis

M.V. Apanasovicha, T.A. Letkovskayab, Yu.L. Denisovac

aBelarusian State Medical University, Minsk, Belarus
bMD, PhD, Associate Professor, Belarusian State Medical University, Minsk, Belarus
cMD, PhD, DMSci, Professor, Belarusian State Medical University, Minsk, Belarus

https://doi.org/10.32993/dentist.2024.3(54).6

ABSTRACT
The relationship between periodontal diseases and general somatic pathology, including autoimmune rheumatic diseases, has been actively studied in recent decades. A special place in these studies is given to rheumatoid arthritis (RA) as the key problem of modern rheumatology, because advances in the study of this nosology significantly influence on the development of not only rheumatology, but also clinical medicine in general.
The aim of the study. To analyze microscopic changes in periodontal tissues of laboratory animals with adjuvant-induced arthritis.
Objects and methods. Female Wistarn rats weighing 60-70 g, fed the usual vivarium diet, were selected as the object of the study. All animals participating in the experiment were divided into three groups. In the first, control group, the animals were not subjected to any influences. Experimental periodontitis was modeled in animals of the second group. In the third group, experimental periodontitis in combination with adjuvant-induced arthritis (AIA) was modeled.
Results and discussion. When conducting a microscopic examination in the main group, various pathological changes were identified, which included both damage of the gingival epithelium and subepithelial periodontal tissues.
Conclusion.  The analysis of the experimental study results revealed a significant deterioration in the condition of the periodontal tissues of laboratory animals with AIA and experimental periodontitis. The obtained morphological data on changes in the periodontal tissues of laboratory animals show a higher degree of inflammation in the main group (AIA + experimental periodontitis) compared to the control group (experimental periodontitis).

Keywords: periodontitis, rheumatoid arthritis, experimental periodontitis, adjuvant-induced arthritis

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Correspondence to:  Е-mail: apanasovi4@gmail.com