Stomatologist № 2 (37) – 2020, pp. 51-54                                                                                                                            SCIENTIFIC PUBLICATION

Systemic inflammatory response syndrome in patients with odontogenic phlegmons the maxillofacial region

A.A. Kabanovaa, I.O. Pohodenko-Chudakovab, S.A. Kabanovaa

aMD, PhD, Associate Professor, Vitebsk State Medical University, Vitebsk, Belarus
bMD, PhD, DMSci, Professor, Belarusian State Medical University, Minsk, Belarus

https://doi.org/10.32993/stomatologist.2020.2(37).7

ABSTRACT
The aim of the study is to determine the features of the development of systemic inflammatory response syndrome (SIRS) in patients with odontogenic phlegmons of the maxillofacial region.
Objects and methods. Surveyed 158 patients with infectious-inflammatory process of maxillofacial area and neck, which were divided into 3 groups: 1 group (96 people) – with acute purulent odontogenic osteomyelitis of mandible complicated by the phlegmon cellular spaces to one space, group 2 (36 patients) with acute purulent odontogenic osteomyelitis of mandible complicated by the phlegmon of several (2–4) cellular spaces, group 3 (26 people) – with acute purulent odontogenic osteomyelitis of the mandible complicated by the phlegmon of bottom of cavity of mouth. Laboratory tests of patients’ blood (general and biochemical analyses) were performed. Based on the general analysis of blood was carried out calculation of integral indices of intoxication. Determination of interleukin-8 and procalcitonin levels was performed using an enzyme immunoassay. The level of activity of blood elastase and oral fluid was studied.
Results and discussion. Acute odontogenic osteomyelitis, complicated by phlegmon of the adjacent soft tissues, is characterized by the development of SIRS. With phlegmons of one cellular space it develops in 9.0% of patients, with phlegmons of 2–4 cellular spaces – in 36.0%, with phlegmons of the bottom of the oral cavity – in 80.0%.
Conclusion. The development of odontogenic infectious diseases of the maxillofacial region is accompanied by SIRS. To prevent the development of severe complications, it is necessary to take into account the localization, prevalence of the process, as well as the appearance of laboratory markers of impaired functioning of macroorganism systems. The most promising indicators for this purpose should be considered the level of albumin, procalcitonin, interleukin-8 and serum elastase activity, which requires further directed research.

Keywords: systemic inflammatory response syndrome, infectious-inflammatory process, maxillofacial region

References

  1. Beznoshhenko G.B. Sindrom sistemnogo vospalitel’nogo otveta v akusherskoj klinike: reshennye voprosy i nereshennye problem [Syndrome of a systemic inflammatory response in an obstetric clinic: resolved issues and unresolved problems]. Rossijskij vestnik akushera-ginekologa ‒ Russian Bulletin of the Obstetrician-Gynecologist. 2018, no. 8 (4), pp. 6–10.
  2. Vjalov S.S. Diagnosticheskoe znachenie laboratornyh issledovanij: ucheb. Posobie. 2-e izd. [The diagnostic value of laboratory research: textbook. 2nd ed.]. M.: MEDpress-inform, 2016. 320 p.
  3. Ponasenko A.V., Sinickij M.Ju., Hutornaja M.V., Barbarash O.L. Geneticheskie makery sistemnoj vospalitel’noj reakcii v kardiohirurgii (obzor) [Genetic brokers of systemic inflammatory response in cardiac surgery (review)]. Obshhaja reanimatologija – General resuscitation. 2017, no. 13 (6), pp. 48–59.
  4. Goncharov M.Ju., Sakovich V.P., Levchik E.Ju. Sindrom sistemnogo vospalitel’nogo otveta v hirurgicheskom lechenii nespecificheskih gnojnyh zabolevanij pozvonochnika [Systemic inflammatory response syndrome in the surgical treatment of non-specific purulent spinal diseases]. Acta Biomedica Scientifica. 2012, no. 4 (2), pp. 39–42.
  5. Kabanova A.A. Diagnosticheskaja znachimost’ jelastaznoj aktivnosti syvorotki krovi i rotovoj zhidkosti pacientov s infekcionno-vospalitel’nymi processami cheljustno-licevoj oblasti razlichnoj rasprostranennosti [Diagnostic significance of the elastase activity of blood serum and oral fluid of patients with infectious and inflammatory processes of the maxillofacial region of varying prevalence]. Stomatolog. Minsk. – Stomatologist. Minsk. 2019, no. 3 (34), pp. 46–50.
  6. Pohoden’ko-Chudakova I.O. Klinicheskoe rukovodstvo: diagnostika, prognozirovanie i lechenie tjazhelyh oslozhnenij infekcionnovospalitel’nyh processov cheljustno-licevoj oblasti i shei: monografija Pod red. I.O. Pohoden’ko-Chudakovoj [Clinical management: diagnosis, prognosis and treatment of severe complications of infectious and inflammatory processes of the maxillofacial region and neck: monograph. Edited by I.O. Pohodenko-Chudakova]. Minsk: Izd. Centr BGU, 2016. 398 p.
  7. Petrie A, Sabin C. Medical Statistics at a Glance. 3rd ed. Oxford: Wiley Blackwell, 2009. 183 p.

Correspondence to:  E-mail: arinakabanova@mail.ru